Is Pineapple Express real life or is it just fantasy? The correct answer is yes on both accounts. Until Seth Rogen and James Franco (with a hand from Danny McBride), smoked themselves silly in the film with the same name, Pineapple Express did not exist. However, once the film came out, growers strove to create a potent, psychoactive strain that the films stars described as “the dopest dope.” Equal parts Trainwreck and Hawaiian, with the occasional Sour Diesel cut, most versions of Pineapple Express will likely carry their own, unique character traits. So be wary.