What Can CBD Oil Do for Fibromyalgia Sufferers?

Fibromyalgia is a disorder characterized by widespread pain, exhaustion, poor sleep quality, and cognitive difficulties that sufferers often experience as brain fog. It is a contentious condition, with medical experts often disagreeing about what constitutes a diagnosis of fibromyalgia, and some debating its existence at all.

Problematically, the FDA-approved drugs traditionally used to treat fibromyalgia have limited efficacy, with commonly used first-line medications such as Cymbalta and Lyrica offering little respite from prevailing symptoms such as pain. Fibromyalgia patients often also complain of side effects associated with these medications.

For the estimated 2% to 4% of the global population who suffer from this condition, the majority of whom are women, there is an increasing interest in alternative therapies that may provide relief from the symptoms. Cannabidiol (CBD) oil is currently attracting attention as an alternative form of treatment.

Research Overview

There is still no research specifically investigating CBD oil as al treatment for fibromyalgia. However,  In 2018, research was published in the Journal of Clinical Rheumatology suggesting medicinal cannabis may represent an effective treatment for the illness.

There is also a solid body of evidence that indicates CBD may provide alleviation for certain symptoms associated with fibromyalgia, such as pain, sleep disruptions, anxiety, and depression.


The Studies

The brain is one of the key areas affected by fibromyalgia, with brain inflammation contributing to pain and brain fog. Recent research suggests that microglia in the brain and spinal cord play a role in fibromyalgia. When glial cells become activated, they can contribute to inflammation by amplifying pain signaling and transmission.

CB2 receptors within the body can modulate microglial cell function. One 2016 study in the Swiss journal Cellular and Molecular Life Sciences suggested that therapeutic strategies aimed at CB2 receptors could provide a promising treatment for inflammation. The therapeutic effects of CBD on inflammation have been documented in a range of studies, such as one published in 2015 in the Elsevier journal Bioorganic and Medicinal Chemistry.

In addition, CBD has been shown to offer neuroprotective properties and stimulate cell repair in the brain. This could improve brain function in fibromyalgia patients. CBD oil may also diminish anxiety and depressive behaviors by boosting anandamide signaling, according to a 2012 study published in the Nature journal Translational Psychiatry. Anandamide is a neurotransmitter that facilitates homeostasis and balanced mood.

In addition to helping to ease inflammation in the body, CBD oil can reduce neuropathic pain, which arises from damaged or malfunctioning nerves. Some fibromyalgia sufferers experience neuropathic pain as one of their symptoms.

Fibromyalgia sufferers also often experience difficulty with sleep. In a March 2019 study, published in the Elsevier journal Epilepsy Research, a single, large dose of CBD induced sleepiness among 30 percent of participants who suffered from treatment-resistant epilepsy. In another clinical trial with healthy volunteers, however, a single large dose of CBD did not create any change in sleep or wake cycles. CBD oil may help fibromyalgia sufferers with sleep, though further research is needed.

Chronic pain is also often accompanied by other comorbidities: anxiety or depression are present in almost 80 percent of the chronic pain population. The co-existence of pain and depression is particularly true for fibromyalgia patients. CBD can help to alleviate anxiety in this population. In one 2017 human study, 300 milligrams of CBD taken orally caused a measurable drop in anxiety and cortisol levels.

Patient Perspectives

For Felicity Adams, whose name has been changed for this article, living with fibromyalgia represented a challenge which was only rendered more difficult by medication triggering an unwelcome entourage of side effects.

I wanted to get off Plaquenil because I could barely eat anything anymore. I had permanent heartburn from the pills,” Adams told Weedmaps News. Finding a treatment that would provide her with relief without causing further detriment to her health was essential. “I wanted to use something that was more natural and would not cause permanent damage.”

She reached out to the Apollo Cannabis Clinic in Ontario and was prescribed CBD oil for daytime use to manage her pain, and CBD with higher THC content at night to assist with sleep.

CBD oil has helped in both the management of her fibromyalgia symptoms, and addressed the side effects caused by her medication.

”I always had digestive issues and now, I can eat almost anything without having gastric pain (such as diarrhea or heartburn),” Adams said.

She also notes that she feels energized after using CBD in the morning, without experiencing cognitive difficulty. ”If I take naproxen for pain, I always end up with a foggy brain. With CBD oil, I have more focus.” Adams concedes that the only side effect she has experienced as a result of taking CBD is a dry mouth, but that regular hydration helps to abate this.

What the Experts Say


Dr. George Habib is the co-author of a 2018 retrospective review study in the Journal of Clinical Rheumatology investigating medical cannabis as a treatment for fibromyalgia and believes it offers fibromyalgia patients hope. ”In general, the impression (from the study) was that this type of medication is more effective than pregabalin and duloxetine,” Habib said.

While there is a still a need for larger randomized trials, Habib, a rheumatologist in Netanya, Israel, believes that the research is promising and that it is worth trying medicinal cannabis for fibromyalgia soon after diagnosis, rather than considering it as an option when opioids fail.

Habib does point out that the patients in the study consumed oil containing both CBD and THC extracts. “A small fraction of our patients used oil, and mostly containing THC, so only a very small number of patients used pure CBD oil,” he said.

Dr. Ginevra Liptan, director of The Frida Center for Fibromyalgia and author of “The FibroManual: A Complete Fibromyalgia Treatment Guide For You…And Your Doctor,” reported that many of her patients have experienced relief from symptoms such as muscle tension, pain, anxiety, and insomnia as a result of combining CBD oil with their mainstream medications. Like Habib, however, she emphasizes that CBD oil appears to be more effective when teamed with THC.

“CBD oil on its own, without any other medications or treatments, typically does not give strong analgesic effects,” Liptan explained.  “Successful pain relief without any additional prescription medications usually requires products that contain some amount of THC in addition to the CBD.”

She, therefore, endorses the use of full-spectrum CBD oils for fibromyalgia. “I see much greater benefit from full-spectrum CBD oils, which contain other cannabinoids and sometimes trace amounts of THC, compared to the CBD isolates, which do not have the synergistic effects of the whole plant extract.”

Liptan also notes that the extent to which patients experience relief varies from patient to patient. Some notice only a mild improvement in their pain, while others notice significant pain relief. While cautious not to depict CBD oil as a panacea, Liptan emphasizes that CBD oil represents a safe form of pain relief for fibromyalgia and that it is definitely worth consideration as a treatment.

The Bottom Line

There is still a lack of conclusive clinical evidence that CBD oil is an effective treatment for fibromyalgia. However, early studies and anecdotal evidence from patients are promising and indicate that CBD oil, particularly full-spectrum CBD,  may reduce pain and inflammation, support healthy sleep, and improve mood.