{"id":1696,"date":"2020-06-25T22:55:23","date_gmt":"2020-06-25T22:55:23","guid":{"rendered":"https:\/\/weedmaps.com\/learn\/cbd\/is-it-possible-to-have-a-marijuana-allergy"},"modified":"2026-02-22T14:53:28","modified_gmt":"2026-02-22T14:53:28","slug":"marijuana-allergy","status":"publish","type":"post","link":"https:\/\/wmlearnver2.wpengine.com\/cannabis-and-your-body\/marijuana-allergy","title":{"rendered":"Is it possible to have a marijuana allergy?"},"content":{"rendered":"<div id=\"bsf_rt_marker\"><\/div>\n<p class=\"wp-block-paragraph\">As cannabis becomes more common and less taboo, veteran and novice consumers alike are becoming more aware of the way human bodies react to the plant. Those who experience seasonal, plant, or food allergies may wonder if it's possible to be allergic to cannabis and what the signs and symptoms of a cannabis allergy might be.<\/p>\n\n\n\n<h2 class=\"wm-article-table-of-contents-header\" id=\"cannabis-allergies-what-we-know-so-far\">\n\tCannabis allergies: what we know so far<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Though the research thus far is limited, we do know that cannabis allergies exist. Cannabis has a long, storied history of both stigma and mystique, with a wide range of effects and side effects that have been attributed to the plant over the years. Some effects attributed to cannabis have been accurate, <a href=\"https:\/\/news.weedmaps.com\/2018\/08\/blunt-truths-chapter-1-harry-anslinger-the-prohibition-cop-with-nothing-to-prohibit\/\">others completely fabricated<\/a>.<\/p>\n\n\n\t\t\t<figure class=\"wp-block-image size-large\">\t\t\t<a href=\"https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?ssl=1\" data-modal-open=\"lightbox_1697\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?fit=640%2C427&ssl=1\" srcset=\"https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?w=1600&ssl=1 1600w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?resize=300%2C200&ssl=1 300w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?resize=1024%2C682&ssl=1 1024w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?resize=768%2C512&ssl=1 768w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?resize=1536%2C1023&ssl=1 1536w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?w=1280&ssl=1 1280w\" sizes=\"(min-width: 768px) 476px, (min-width: 1218px) 772px, 100vw\" alt=\"marijuana plant\" title=\"Click to see a larger version of the image\">\n\t\t\t<\/a><cite>Photo by: Gina Coleman\/Weedmaps<\/cite><figcaption>Cannabis is the same as any other plant which, though typically beneficial, may cause allergies in some consumers.<\/figcaption><\/figure>\t\t\t<div id=\"lightbox_1697\" data-modal data-modal-hide-heading data-modal-manual-close hidden>\n\t\t\t\t<h2>Image lightbox<\/h2>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?fit=640%2C427&ssl=1\" srcset=\"https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?w=1600&ssl=1 1600w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?resize=300%2C200&ssl=1 300w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?resize=1024%2C682&ssl=1 1024w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?resize=768%2C512&ssl=1 768w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?resize=1536%2C1023&ssl=1 1536w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2020\/07\/032A3082-2.jpg?w=1280&ssl=1 1280w\" sizes=\"100vw\" alt=\"marijuana plant\">\n\t\t\t\t<button role=\"button\" class=\"a11y-modal__close-btn\" data-modal-close-btn>\n\t\t\t\t\t<svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"currentColor\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M13.414 12l4.293 4.293a1 1 0 01-1.414 1.414L12 13.414l-4.293 4.293a1 1 0 11-1.414-1.414L10.586 12 6.293 7.707a1 1 0 011.414-1.414L12 10.586l4.293-4.293a1 1 0 011.414 1.414L13.414 12z\"\/><\/svg>\n\t\t\t\t<\/button>\n\t\t\t<\/div>\n\n\n<p class=\"wp-block-paragraph\"><span style=\"font-weight: 400\">If LTPs aren't the only source of cannabis allergies, what other factors are at play? You've probably heard a lot about <\/span><a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/terpenes\"><span style=\"font-weight: 400\">terpenes<\/span><\/a><span style=\"font-weight: 400\"> lately <\/span><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">But the possibility of cannabis allergy is neither an overblown anti-marijuana scare tactic nor an indication that the plant is less healthful or therapeutic than we thought. Rather, it is the same as any other&nbsp; typically beneficial plant that may cause allergies in some people.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">So let's look at the available research to better understand the mechanisms that cause allergic reactions in some cannabis consumers.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-lipid-transfer-proteins\"><strong>Lipid transfer proteins<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Several recent studies have identified <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20582490\">lipid transfer proteins<\/a> (LTPs) as probable allergens in cannabis. LTPs are often found in plant-based foods and pollen. They cause allergic reactions in humans by triggering an overproduction of antibodies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In a March 2019 study published in The Journal of Allergy &amp; Clinical Immunology: In Practice, 120 cannabis allergy patients and 62 healthy control subjects were given a <a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/hemp\/\">hemp<\/a> extract through three different administration tests, including a skin-prick test. The <a href=\"https:\/\/weedmaps.com\/learn\/the-plant\/hemp-vs-marijuana\/\">hemp extract<\/a> was rich in an LTP prevalent in cannabis. The study concluded that about <a href=\"https:\/\/www.jaci-inpractice.org\/article\/S2213-2198(18)30594-4\/abstract\">80% of cannabis allergy patients tested were sensitive<\/a> to the protein.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In short, this study suggests that LTPs aren't the only cannabis allergen, but play a prominent role in triggering allergic reactions to cannabis.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-cross-reactivity\"><strong>Cross-Reactivity<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Other studies have shown similar results when testing cannabis LTP sensitivity among cannabis allergy patients. Some of these studies also show a recurring cross-reactivity<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29122396\"> to other plants<\/a> that contain similar proteins, according to a December 2017 study published in the French Journal of Clinical Pneumology. Cross-reactivity occurs when someone has an allergic reaction to similar proteins from different substances. About 45% of cannabis allergic patients in the Journal of Allergy &amp; Clinical Immunology study also reported allergic reactions to plant-derived foods.<\/p>\n\n\n\t\t\t<figure class=\"wp-block-image \">\t\t\t<a href=\"https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?ssl=1\" data-modal-open=\"lightbox_3672\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?fit=640%2C360&ssl=1\" srcset=\"https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?w=2560&ssl=1 2560w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?resize=300%2C169&ssl=1 300w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?resize=1024%2C576&ssl=1 1024w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?resize=768%2C432&ssl=1 768w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?resize=1536%2C864&ssl=1 1536w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?resize=2048%2C1152&ssl=1 2048w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?w=1280&ssl=1 1280w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?w=1920&ssl=1 1920w\" sizes=\"(min-width: 768px) 476px, (min-width: 1218px) 772px, 100vw\" alt=\"Nugs and joint leaning on pile of mangos\" title=\"Click to see a larger version of the image\">\n\t\t\t<\/a><cite>Photo by: Gina Coleman\/Weedmaps<\/cite><\/figure>\t\t\t<div id=\"lightbox_3672\" data-modal data-modal-hide-heading data-modal-manual-close hidden>\n\t\t\t\t<h2>Image lightbox<\/h2>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?fit=640%2C360&ssl=1\" srcset=\"https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?w=2560&ssl=1 2560w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?resize=300%2C169&ssl=1 300w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?resize=1024%2C576&ssl=1 1024w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?resize=768%2C432&ssl=1 768w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?resize=1536%2C864&ssl=1 1536w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?resize=2048%2C1152&ssl=1 2048w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?w=1280&ssl=1 1280w, https:\/\/i0.wp.com\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2018\/07\/CRTV-3358_Social-710_Project-Terpene_myrcene_16x9-scaled.jpg?w=1920&ssl=1 1920w\" sizes=\"100vw\" alt=\"Nugs and joint leaning on pile of mangos\">\n\t\t\t\t<button role=\"button\" class=\"a11y-modal__close-btn\" data-modal-close-btn>\n\t\t\t\t\t<svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"currentColor\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M13.414 12l4.293 4.293a1 1 0 01-1.414 1.414L12 13.414l-4.293 4.293a1 1 0 11-1.414-1.414L10.586 12 6.293 7.707a1 1 0 011.414-1.414L12 10.586l4.293-4.293a1 1 0 011.414 1.414L13.414 12z\"\/><\/svg>\n\t\t\t\t<\/button>\n\t\t\t<\/div>\n\n\n<p class=\"wp-block-paragraph\">A 2013 study from the journal Internal Archives of Allergy and Immunology tested 21 patients with food allergies for reactivity to cannabis LTPs. Twelve of the 21 test subjects were <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23549061?dopt=Abstract\" target=\"_blank\" rel=\"noreferrer noopener\">also allergic to cannabis<\/a>, and all 12 had more severe reactions to their food triggers than those without a cannabis allergy.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A 2008 study from the same journal tested 32 subjects for an allergic reaction to cannabis LTPs, as well as tomato, peach peel, and pollen extracts. All subjects sensitive to tomato allergens were <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18268387?dopt=Abstract\" target=\"_blank\" rel=\"noreferrer noopener\">also sensitive to cannabis<\/a>. Cross-reactivity to peach peel and cannabis was also prominent.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These studies provide further evidence that LTPs play a central role in cannabis allergies, and may be the main culprit of cross-reactivity with other food allergies.&nbsp;&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-terpenes\"><strong>Terpenes<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">LTPs aren't the only source of cannabis allergies, other factors are at play as well. You've probably heard <a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/terpenes\/\" target=\"_blank\" rel=\"noreferrer noopener\">a lot about terpenes<\/a> lately \u2014 the compounds responsible for the aroma and flavor of cannabis and a variety of other plants. Similar to prominent <a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/cannabinoid\/\" target=\"_blank\" rel=\"noreferrer noopener\">cannabis compounds<\/a> like <a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/cbd\/\" target=\"_blank\" rel=\"noreferrer noopener\">cannabidiol (CBD)<\/a> and <a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/tetrahydrocannabinol-thc\/\" target=\"_blank\" rel=\"noreferrer noopener\">tetrahydrocannabinol (THC)<\/a>, terpenes have a wide variety of purported medicinal benefits. They may also be responsible, at least partially, for allergic reactions to cannabis in some users.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The terpene linalool, for example, has been found to elicit allergic reactions when oxidized, or exposed to the air. A 2010 study of linalool placed varying concentrations of oxidized <a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/linalool\/\" target=\"_blank\" rel=\"noreferrer noopener\">linalool<\/a> patches on the skin of 1,151 dermatitis patients, with 5 to 7% of <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1111\/j.1600-0536.2009.01657.x\" target=\"_blank\" rel=\"noreferrer noopener\">patients testing positive for linalool sensitivity<\/a>. A similar study from 2016 tested oxidized linalool and oxidized <a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/limonene\/\" target=\"_blank\" rel=\"noreferrer noopener\">limonene<\/a>, another prominent terpene in cannabis, on a group of 2,900 dermatitis patients, and found that <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26918793\" target=\"_blank\" rel=\"noreferrer noopener\">281 of them had allergic reactions<\/a> to one or both of the terpenes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Findings like these don't necessarily point to a high chance that terpenes are a prominent contributor to most cannabis allergies, but they do present a definite possibility that some allergic reactions to cannabis, especially skin allergies, are terpene-related.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-signs-and-symptoms-of-a-cannabis-allergy\"><strong>Signs and symptoms of a cannabis allergy<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Depending on the route through which it reacts with the body \u2014 i.e. skin contact, inhalation of pollen, etc. \u2014 cannabis is reported to produce a wide variety of allergy symptoms, most of which are typical of other allergies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In a report from Canada's CTV News on the <a href=\"https:\/\/www.ctvnews.ca\/health\/under-recognized-and-under-diagnosed-could-you-be-allergic-to-marijuana-1.3856853\" target=\"_blank\" rel=\"noreferrer noopener\">emerging trend of cannabis allergies<\/a> in the <a href=\"https:\/\/news.weedmaps.com\/2018\/10\/living-and-loving-the-cannada-day-legalization-experience\/\" target=\"_blank\" rel=\"noreferrer noopener\">post-legalization era<\/a>, Toronto-based immunologist and allergy expert Dr. Gordon Sussman said that more exposure to marijuana among the general public will inevitably lead to more reported cases of cannabis allergies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sussman has seen a rising number of cannabis-sensitive patients over the past ten years and is actively studying undiagnosed cannabis allergies to raise awareness and better prepare physicians.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cIf you look at a study done out of Colorado, about 10% of people just with passive exposure did have [cannabis] allergy symptoms,\u201d Dr. Sussman said. In the same CTV report, Dr. Sussman said that skin contact with the cannabis plant can cause irritation ranging from a mild itch to hives and puffy eyes. Smoking cannabis or inhaling cannabis pollen can lead to sneezing and a runny nose as well as wheezing, shortness of breath, and asthma symptoms. When cannabis patients eat hemp seed or other cannabis products, it's also possible to experience anaphylactic symptoms.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-to-do-if-you-re-allergic-to-cannabis\"><strong>What to do if you're allergic to cannabis<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Sussman told CTV News that simply avoiding marijuana is the only \u201ctruly effective way to deal with a marijuana allergy.\u201d The good news is, if you test positive for cannabis allergies and experience common allergy symptoms, a doctor or allergy specialist may be able to prescribe common allergy treatments \u2014 i.e., nasal spray, antihistamines, or EpiPens, if necessary \u2014 to reduce or eliminate symptoms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>Major contributions from <a href=\"https:\/\/weedmaps.com\/learn\/subject-matter-expert\/apoe\" target=\"_blank\" rel=\"noreferrer noopener\">Dr. Adie Rae<\/a>.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>As cannabis becomes more common and less taboo, veteran and novice consumers alike are becoming more aware of the way human bodies react to the plant. Those who experience seasonal, plant, or food allergies may wonder if it's possible to be allergic to cannabis and...<\/p>\n","protected":false},"author":15,"featured_media":1699,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[137],"tags":[710,1200,1201,1202,1203,1204],"class_list":["post-1696","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cannabis-and-your-body","tag-cannabis-health-risks","tag-marijuana-allergy","tag-cannabis-allergy-symptoms","tag-cannabis-sensitivity","tag-thc-allergic-reaction","tag-cannabinoid-reactions"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Is It Possible to Have a Marijuana Allergy?<\/title>\n<meta name=\"description\" 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