{"id":129,"date":"2019-09-05T23:11:23","date_gmt":"2019-09-05T23:11:23","guid":{"rendered":"https:\/\/wmlearnver2.wmmota.com\/?p=129"},"modified":"2026-04-18T00:24:46","modified_gmt":"2026-04-18T00:24:46","slug":"cbd-oil-for-depression","status":"publish","type":"post","link":"https:\/\/weedmaps.com\/learn\/cbd\/cbd-oil-for-depression","title":{"rendered":"CBD oil and depression"},"content":{"rendered":"<div id=\"bsf_rt_marker\"><\/div>\n<p>Major depressive disorder is the leading cause of disability among Americans aged 15 to 44. It affects approximately <a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/adaa.org\/about-adaa\/press-room\/facts-statistics\" target=\"_blank\">7% of Americans<\/a> per year, as well as more than <a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression\" target=\"_blank\">300 million people<\/a> worldwide. While this condition can develop at any age, the average onset is 32 years old; it is more prevalent in women than in men.<\/p>\n\n\n\n<p>Since antidepressant medications first became available in the 1950s, many other options have become available, including talk therapy and relaxation techniques. Medication continues to be a leading course of treatment but non-pharmaceutical treatment is important as up to <a href=\"https:\/\/www.camh.ca\/en\/camh-news-and-stories\/unraveling-and-treating-depression\">4<\/a><a rel=\"noreferrer noopener\" aria-label=\"0 (opens in a new tab)\" href=\"https:\/\/www.camh.ca\/en\/camh-news-and-stories\/unraveling-and-treating-depression\" target=\"_blank\">0<\/a><a href=\"https:\/\/www.camh.ca\/en\/camh-news-and-stories\/unraveling-and-treating-depression\">% of patients<\/a> with depression are \u201ctreatment-resistant\u201d \u2014 meaning their symptoms do not improve after trying a minimum of two antidepressant medications.&nbsp;<\/p>\n\n\n\t\t\t<figure class=\"wp-block-image \">\t\t\t<a href=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?ssl=1\" data-modal-open=\"lightbox_492\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?fit=640%2C360&ssl=1\" srcset=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?w=1600&ssl=1 1600w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?resize=300%2C169&ssl=1 300w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?resize=768%2C432&ssl=1 768w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?resize=1024%2C576&ssl=1 1024w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?w=1280&ssl=1 1280w\" sizes=\"(min-width: 768px) 476px, (min-width: 1218px) 772px, 100vw\" alt=\"Weed leaf on white colored brain\" title=\"Click to see a larger version of the image\">\n\t\t\t<\/a><cite>Photo by: Gina Coleman\/Weedmaps<\/cite><figcaption>CBD as a tool in the fight against depression is now a key area of interest for consumers and researchers alike.&nbsp;<\/figcaption><\/figure>\t\t\t<div id=\"lightbox_492\" data-modal data-modal-hide-heading data-modal-manual-close hidden>\n\t\t\t\t<h2>Image lightbox<\/h2>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?fit=640%2C360&ssl=1\" srcset=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?w=1600&ssl=1 1600w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?resize=300%2C169&ssl=1 300w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?resize=768%2C432&ssl=1 768w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?resize=1024%2C576&ssl=1 1024w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CannabisInYourBody-22.jpg?w=1280&ssl=1 1280w\" sizes=\"100vw\" alt=\"Weed leaf on white colored brain\">\n\t\t\t\t<button role=\"button\" class=\"a11y-modal__close-btn\" data-modal-close-btn>\n\t\t\t\t\t<svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"currentColor\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M13.414 12l4.293 4.293a1 1 0 01-1.414 1.414L12 13.414l-4.293 4.293a1 1 0 11-1.414-1.414L10.586 12 6.293 7.707a1 1 0 011.414-1.414L12 10.586l4.293-4.293a1 1 0 011.414 1.414L13.414 12z\"\/><\/svg>\n\t\t\t\t<\/button>\n\t\t\t<\/div>\n\n\n<p>Cannabidiol (CBD), particularly CBD-rich cannabis oil, as a tool in the fight against depression is now a key area of interest for consumers and researchers alike.&nbsp;<\/p>\n\n\n\n<h2 class=\"wm-article-table-of-contents-header\" id=\"research-overview\">\n\tResearch overview <\/h2>\n\n\n\n<p>Numerous animal models have shown that CBD may yield <a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24923339\" target=\"_blank\">great psychiatric potential<\/a>, offering anti-anxiety and antidepressant-like properties. The effect of CBD on <a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6326553\/\" target=\"_blank\">serotonin 1A receptors<\/a> may be key to these potential benefits.\u00a0<\/p>\n\n\n\n<p>A growing body of research suggests that deficiencies in the <a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19839936\" target=\"_blank\">endocannabinoid system<\/a> (ECS) may produce depressive responses. Clinical and preclinical data suggest that cannabinoid receptor signaling may be an ideal target for developing new pharmacotherapy options for both anxiety and mood disorders.&nbsp;<\/p>\n\n\n\n<h2 class=\"wm-article-table-of-contents-header\" id=\"the-studies\">\n\tThe studies<\/h2>\n\n\n\n<p><a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/link.springer.com\/article\/10.1007%2Fs12035-018-1143-4\" target=\"_blank\">A 2018 study<\/a> stated that available antidepressant medications have a significant time lag in terms of therapeutic response and are often relatively inefficient. Their goal was to study whether CBD could induce rapid, yet sustained, antidepressant-like results in male rodents bred to develop depression-like symptoms.<\/p>\n\n\n\n<p>After a single dose, acute antidepressant effects were observed within 30 minutes. Also occurring was an increase in brain-derived neurotrophic factor (BDNF), which is a protein that plays a critical <a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15145621\" target=\"_blank\">role in mood disorders<\/a>. The researchers concluded that CBD offers a promising therapeutic profile as a potential fast-acting antidepressant treatment option.&nbsp;<\/p>\n\n\n\t\t\t<figure class=\"wp-block-image \">\t\t\t<a href=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?ssl=1\" data-modal-open=\"lightbox_525\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?fit=640%2C360&ssl=1\" srcset=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?w=1600&ssl=1 1600w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?resize=300%2C169&ssl=1 300w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?resize=768%2C432&ssl=1 768w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?resize=1024%2C576&ssl=1 1024w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?w=1280&ssl=1 1280w\" sizes=\"(min-width: 768px) 476px, (min-width: 1218px) 772px, 100vw\" alt=\"weed and pills\" title=\"Click to see a larger version of the image\">\n\t\t\t<\/a><cite>Photo by: Gina Coleman\/Weedmaps<\/cite><figcaption>Studies have shown that CBD offers a promising therapeutic profile as a potential fast-acting antidepressant treatment option.&nbsp;<\/figcaption><\/figure>\t\t\t<div id=\"lightbox_525\" data-modal data-modal-hide-heading data-modal-manual-close hidden>\n\t\t\t\t<h2>Image lightbox<\/h2>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?fit=640%2C360&ssl=1\" srcset=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?w=1600&ssl=1 1600w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?resize=300%2C169&ssl=1 300w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?resize=768%2C432&ssl=1 768w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?resize=1024%2C576&ssl=1 1024w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-516_Legal-News_Piils_094.jpg?w=1280&ssl=1 1280w\" sizes=\"100vw\" alt=\"weed and pills\">\n\t\t\t\t<button role=\"button\" class=\"a11y-modal__close-btn\" data-modal-close-btn>\n\t\t\t\t\t<svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"currentColor\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M13.414 12l4.293 4.293a1 1 0 01-1.414 1.414L12 13.414l-4.293 4.293a1 1 0 11-1.414-1.414L10.586 12 6.293 7.707a1 1 0 011.414-1.414L12 10.586l4.293-4.293a1 1 0 011.414 1.414L13.414 12z\"\/><\/svg>\n\t\t\t\t<\/button>\n\t\t\t<\/div>\n\n\n<p>Another <a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0278584618301167\" target=\"_blank\">2018 study<\/a>, conducted on mice, examined in the mechanisms of CBD-induced antidepressant-like effects, investigating the role of serotonin and noradrenaline. Researchers found that CBD likely improves symptoms of depression through the action of serotonin. When CBD was administered with a serotonergic, or any agent that modifies the effects of serotonin, a synergistic effect was observed.&nbsp;&nbsp;<\/p>\n\n\n\n<h2 class=\"wm-article-table-of-contents-header\" id=\"what-the-experts-say\">\n\tWhat the experts say<\/h2>\n\n\n\n<p>Dr. Bonni Goldstein, medical director of California-based Canna-Centers and a subject matter adviser for Weedmaps, said she knows of anecdotes of people who said they used CBD to treat depression. \u201cPreclinical animal data reports that CBD can have antidepressant effects. There are many anecdotal reports of patients using CBD successfully to treat depression but clinical trials in humans are lacking,\u201d said Goldstein, who is also author of \u201c<a href=\"https:\/\/www.amazon.ca\/Cannabis-Revealed-misunderstood-everything-epilepsy\/dp\/0998141305\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">Cannabis Revealed<\/a>.\u201d<\/p>\n\n\n\n<p>\u201cFor example, one middle-aged man who found the side effects of antidepressants to be intolerable, experiencing insomnia and decreased sexual function, started using low doses of a 4:1 CBD:THC tincture. He self-reported a 90% improvement of his depression symptoms with no side effects,\u201d she said.&nbsp;<\/p>\n\n\n\t\t\t<figure class=\"wp-block-image \">\t\t\t<a href=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?ssl=1\" data-modal-open=\"lightbox_574\">\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?fit=640%2C360&ssl=1\" srcset=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?w=1600&ssl=1 1600w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?resize=300%2C169&ssl=1 300w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?resize=768%2C432&ssl=1 768w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?resize=1024%2C576&ssl=1 1024w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?w=1280&ssl=1 1280w\" sizes=\"(min-width: 768px) 476px, (min-width: 1218px) 772px, 100vw\" alt=\"\" title=\"Click to see a larger version of the image\">\n\t\t\t<\/a><cite>Photo by: Gina Coleman\/Weedmaps<\/cite><figcaption>There is scientific evidence to suggest that CBD has antidepressant-like effects.<\/figcaption><\/figure>\t\t\t<div id=\"lightbox_574\" data-modal data-modal-hide-heading data-modal-manual-close hidden>\n\t\t\t\t<h2>Image lightbox<\/h2>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?fit=640%2C360&ssl=1\" srcset=\"https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?w=1600&ssl=1 1600w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?resize=300%2C169&ssl=1 300w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?resize=768%2C432&ssl=1 768w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?resize=1024%2C576&ssl=1 1024w, https:\/\/i0.wp.com\/weedmaps.com\/learn\/wp-content\/uploads\/2019\/10\/CRTV-2350_Wellness-CBD-Personas_AirBnB-Day1_171.jpg?w=1280&ssl=1 1280w\" sizes=\"100vw\" alt=\"\">\n\t\t\t\t<button role=\"button\" class=\"a11y-modal__close-btn\" data-modal-close-btn>\n\t\t\t\t\t<svg width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"currentColor\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M13.414 12l4.293 4.293a1 1 0 01-1.414 1.414L12 13.414l-4.293 4.293a1 1 0 11-1.414-1.414L10.586 12 6.293 7.707a1 1 0 011.414-1.414L12 10.586l4.293-4.293a1 1 0 011.414 1.414L13.414 12z\"\/><\/svg>\n\t\t\t\t<\/button>\n\t\t\t<\/div>\n\n\n<p>\"There is scientific evidence to suggest that CBD has antidepressant-like effects,\u201d Rosalia Yoon, Ph.D., a Research Scientist for <a href=\"https:\/\/apollocannabis.ca\/\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\">Apollo Cannabis Clinics<\/a> in Ontario, Canada, told Weedmaps. \u201cFrom a neurophysiological perspective, the endocannabinoid system (ECS) is known to modulate functions associated with cognition, mood, sleep, pain, reward, and motivation; and decreased ECS activity has been postulated to account for some of the symptomatology associated with depression, such as low mood, anhedonia, anxiety, and decreased pain tolerance.\u201d&nbsp;<\/p>\n\n\n\n<p>While studies are limited, \u201cMost of the evidence on the mood regulatory effects of CBD comes from pre-clinical studies. CBD has been demonstrated to exert dose-dependent antidepressant-like effects in animal models of depression in various rodent species,\u201d Yoon explained. \u201cOf note, CBD appears to exert <em>acute<\/em> antidepressant effects, suggesting that it may confer temporal advantages over standard antidepressant medications, for which the onset of action typically occurs 6-8 weeks after initiation of treatment. Further, research has shown that a single dose of CBD has effects lasting up to one week in rodents, suggesting sustained antidepressant effects.\u201d<\/p>\n\n\n\n<p>Yoon also acknowledged the limits of medical research.<\/p>\n\n\n\n<p>\u201cAdmittedly, evidence on the antidepressant effects of CBD in humans remains inconclusive due to a scarcity of randomized, controlled trials, and the evidence comes mostly from anecdotal accounts or evaluation of depression as a secondary measure,\u201d Yoon said. \u201cIn other studies of cannabis, antidepressant effects have been ascribed to THC. For instance, THC and\/or synthetic THC has been reported to elicit an elevated mood in healthy subjects, chronic pain patients, and among those living with <a rel=\"noreferrer noopener\" aria-label=\" (opens in a new tab)\" href=\"https:\/\/pdfs.semanticscholar.org\/c57a\/2e102a9b8dc117cf920281bd1934fcc45456.pdf\" target=\"_blank\">bipolar affective disorder<\/a>.<\/p>\n\n\n\n<p>\u201cConsiderably more human studies need to be conducted in order to fully understand the benefits of CBD in relation to mood regulation. Nevertheless, given the positive pre-clinical evidence and the high safety index of cannabis, CBD holds promise as a therapeutic aid in the management of depressive symptomatology. It should be noted that drug-drug interactions, as well as issues of tolerability and safety with long-term use, are not yet fully understood. As such, CBD should always be used under the care and guidance of a medical doctor, especially when it pertains to the management of mood disorders,\" she said.<\/p>\n\n\n\n<h2 class=\"wm-article-table-of-contents-header\" id=\"bottom-line\">\n\tBottom line <\/h2>\n\n\n\n<p>Overall, anecdotal reports offer insight, as many patients have reported relief following treatment with CBD-rich cannabis products. These products are increasingly being used to treat symptoms of depression, and research indicates cannabinoids may support a more comprehensive, long-term recovery treatment plan.<\/p>\n\n\n\n<p>In preclinical animal studies, CBD has been shown to offer antidepressant-like effects, yet clinical trials are lacking. While CBD shows promise as a potential antidepressant treatment, more research is required in humans.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Major depressive disorder is the leading cause of disability among Americans aged 15 to 44. It affects approximately 7% of Americans per year, as well as more than 300 million people worldwide. While this condition can develop at any age, the average onset is 32...<\/p>\n","protected":false},"author":12,"featured_media":297,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[11],"tags":[1683,1732,1751,1752,1753],"class_list":["post-129","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cbd","tag-cannabidiol-studies","tag-cbd-neurological-research","tag-depression-research","tag-cbd-and-depression","tag-cannabinoid-mood-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CBD Oil For Depression? 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What the research tells us | Weedmaps\" \/>\n<meta property=\"og:description\" content=\"Learn about the potential of CBD oil for depression through a review of current research, patient perspectives, and a look at what medical experts think of CBD and depression.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/weedmaps.com\/learn\/cbd\/cbd-oil-for-depression\" \/>\n<meta property=\"og:site_name\" content=\"Weedmaps\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Weedmaps\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-05T23:11:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-18T00:24:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/wmlearnver2.wpengine.com\/wp-content\/uploads\/2019\/10\/4943_Big-Bear-Pain-Face_326.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1600\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Bonni Goldstein, MD\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@weedmaps\" \/>\n<meta name=\"twitter:site\" content=\"@weedmaps\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Bonni Goldstein, MD\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":[\"Article\",\"BlogPosting\"],\"@id\":\"https:\\\/\\\/weedmaps.com\\\/learn\\\/cbd\\\/cbd-oil-for-depression#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/wmlearnver2.wpengine.com\\\/cbd\\\/cbd-oil-for-depression\"},\"author\":{\"name\":\"Bonni Goldstein, MD\",\"@id\":\"https:\\\/\\\/weedmaps.com\\\/learn\\\/#\\\/schema\\\/person\\\/ad9910f35b40977a3a2c1632886d5b5e\"},\"headline\":\"CBD oil and depression\",\"datePublished\":\"2019-09-05T23:11:23+00:00\",\"dateModified\":\"2026-04-18T00:24:46+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/wmlearnver2.wpengine.com\\\/cbd\\\/cbd-oil-for-depression\"},\"wordCount\":966,\"publisher\":{\"@id\":\"https:\\\/\\\/weedmaps.com\\\/learn\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/weedmaps.com\\\/learn\\\/cbd\\\/cbd-oil-for-depression#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/i0.wp.com\\\/weedmaps.com\\\/learn\\\/wp-content\\\/uploads\\\/2019\\\/10\\\/4943_Big-Bear-Pain-Face_326.jpg?fit=1600%2C900&ssl=1\",\"keywords\":[\"cannabidiol studies\",\"CBD neurological research\",\"depression research\",\"CBD and depression\",\"cannabinoid mood research\"],\"articleSection\":[\"CBD\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/wmlearnver2.wpengine.com\\\/cbd\\\/cbd-oil-for-depression\",\"url\":\"https:\\\/\\\/weedmaps.com\\\/learn\\\/cbd\\\/cbd-oil-for-depression\",\"name\":\"CBD Oil For Depression? 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