{"id":104,"date":"2019-10-04T00:03:28","date_gmt":"2019-10-04T00:03:28","guid":{"rendered":"https:\/\/wmlearnver2.wmmota.com\/?p=104"},"modified":"2026-02-22T15:58:44","modified_gmt":"2026-02-22T15:58:44","slug":"allergic-reaction-to-cbd-oil","status":"publish","type":"post","link":"https:\/\/weedmaps.com\/learn\/cbd\/allergic-reaction-to-cbd-oil","title":{"rendered":"Can you have an allergic reaction to CBD?"},"content":{"rendered":"<div id=\"bsf_rt_marker\"><\/div>\n<p>Whether it's sniffling, watery eyes, itching, or asthma, many of us are all too familiar with symptoms of allergies.&nbsp;<\/p>\n\n\n\n<p>According to the<a href=\"https:\/\/www.aafa.org\/allergy-facts\/\"><strong> <\/strong>Asthma and Allergy Foundation of America<\/a>, allergies are the sixth leading cause of chronic illness in the US. There were 19.2 million adults diagnosed with hay fever in 2021, according to the<a href=\"https:\/\/www.cdc.gov\/nchs\/fastats\/allergies.htm\"><strong> <\/strong>Centers for Disease Control and Prevention<\/a> (CDC). It is <a href=\"https:\/\/www.foodallergy.org\/life-with-food-allergies\/food-allergy-101\/facts-and-statistics\">estimated that 32 million Americans live with food allergies<\/a>; more than 170 foods may lead to an allergic reaction.<\/p>\n\n\n\n<p>Considering the increasing awareness and use of<a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/cbd\"><strong> <\/strong>cannabidiol (CBD)<\/a> and the existing potential for pollen and food allergies, allergy sufferers may wonder whether they are at risk for an allergic reaction to CBD or whether it can provide treatment or relief for other types of allergic reactions.&nbsp;<\/p>\n\n\n\n<p>Though there's not much in the way of allergy research specifically for CBD at this point, the cannabis plant itself has been linked to allergic reactions.&nbsp;<\/p>\n\n\n\n<p>\u201cMarijuana is a plant and produces pollen and one can become allergic to the pollen and the plant, especially if one has pre-existing allergic tendencies,\u201d said Dr. William S. Silvers, clinical professor of medicine in allergy and immunology at the University of Colorado School of Medicine.<\/p>\n\n\n\n<p>That being said, only male marijuana plants produce pollen, and they are exceedingly rare in cannabis and hemp production because they produce less oil and CBD than female plants. Therefore, a consumer's exposure to pollen would be extremely rare.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-cbd-overview\"><strong>CBD overview<\/strong><\/h2>\n\n\n\n<p>CBD is the second-most-prominent <a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/cannabinoid\">cannabinoid derived from the cannabis plant<\/a>, after the intoxicating cannabinoid <a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/tetrahydrocannabinol-thc\">tetrahydrocannabinol (THC)<\/a>. CBD, extracted from marijuana or industrial hemp, has gained popularity for its potential benefits for a number of conditions, including inflammation, arthritic pain, depression, seizures, and anxiety.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh6.googleusercontent.com\/kGtiT9qMgEx5QJr056sXch6l7_ztEmkl8ZJSnb4vdIttGroiR_CzwrTpeNcSjUWQ281oSMNa7ZA0EVNtme-6u8B2NyAXjVrrOsEuA5i4GZRWKvhD832hoc7p7pjjZ9U-p_v0WL50\" alt=\"\"\/><figcaption>There's not much in the way of allergy research specifically for CBD, but the cannabis plant itself has been linked to allergic reactions in some people.&nbsp;Photo by: Gina Coleman\/Weedmaps<\/figcaption><\/figure>\n\n\n\n<p>Though research is still limited in regards to many supposed benefits, in 2018 the FDA approved Epidiolex, an oral CBD solution, to treat seizures associated with two severe types of epilepsy, Dravet syndrome and Lennox-Gastaut syndrome.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-allergies-in-the-body\"><strong>Allergies in the body<\/strong><\/h2>\n\n\n\n<p>A properly functioning immune system works to protect the body from pathogens such as bacteria, viruses, and fungi, and attack these unwanted microorganisms in order to help prevent disease. In the case of allergies, the immune system triggers a reaction to plant pollen and other harmless substances in the environment. The result, depending on the type of allergy, can be a variety of symptoms, including itchy eyes, runny nose, asthma, hives, skin itching, or more severe reactions such as anaphylaxis, which can be life-threatening.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-allergic-reactions-to-cbd\"><strong>Allergic reactions to CBD<\/strong><\/h2>\n\n\n\n<p>Humans commonly experience allergic reactions to many kinds of plant pollen. However, only male cannabis plants produce pollen, whereas female plants are more widely used for oil and cannabinoid production. Large-scale industrial hemp fields may include a variety of mature males (pollen) as well as fertilized females (oil and seeds). The impact of hemp pollen on everyday consumers, as well as the communities that work and live near these production facilities, has not been studied.<\/p>\n\n\n\n<p>People can also develop allergies to some of the <a href=\"https:\/\/weedmaps.com\/learn\/dictionary\/terpenes\">terpenes found in cannabis<\/a>. For instance, researchers from the Duke University School of Medicine found that about 20% of the 100 <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28885310\">people they tested<\/a> had an allergic skin reaction to linalool, whereas 8% had reactions to limonene. These kinds of contact allergies may not be common in the general population, but anyone with these allergies working in the cannabis production industry could have health consequences.<\/p>\n\n\n\n<p>Dr. Gordon Sussman, an allergist in Canada and professor at the University of Toronto, said there is very little published research on CBD allergies. \u201cIt's an unknown area at this point,\u201d he said. \u201cBut we know that cannabis sativa is an allergen and we know that it's a common allergen.\u201d<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/MKGRIc5wEZ8CW27DX0pPyxPNKPVJ_oh1tqzTJ2fgOCpGoMKXtUVGyGcnniR_ok-1OLoZ2lMXpjXnj16MKzsPNwX0iRg-kVWIvfdDdlDa4dbNGZpPruHu6gL8dQDIhp5JJ6o77Af4\" alt=\"\"\/><figcaption>Photo by: Gina Coleman\/Weedmaps<\/figcaption><\/figure>\n\n\n\n<p>Humans commonly experience allergic reactions to many kinds of plant pollen. Only male cannabis plants produce pollen. Most cannabis products, including CBD oil, are made using female plants.<\/p>\n\n\n\n<p>He said that cannabis allergies, like other forms of allergies, can worsen as exposure to the allergen continues. Most people with cannabis allergies suffer from a runny and stuffy nose (rhinitis), eye irritation (conjunctivitis), and sometimes wheezing, Sussman explained. But there have been cases of more severe reactions such as anaphylaxis, which have primarily resulted from ingestion of hemp seeds.&nbsp;<\/p>\n\n\n\n<p>According to a letter entitled \u201c<a href=\"https:\/\/www.annallergy.org\/article\/S1081-1206(18)30024-3\/fulltext\">Marijuana and stoned fruit<\/a>,\u201d written by doctors from the University of California, San Diego, and published in the Annals of Allergy, Asthma, and Immunology in 2018, a 24-year-old man who smoked marijuana daily visited their allergy clinic two weeks following an anaphylactic reaction after eating yogurt with hemp seeds.&nbsp;<\/p>\n\n\n\n<p>\u201cThis was his first known ingestion of hemp seeds. Immediately after consumption, he developed oral pruritus [itching] that progressed to shortness of breath, facial swelling, and pre-syncope [sensation prior to fainting],\u201d the letter stated.<\/p>\n\n\n\n<p>Those with food allergies may also be susceptible to cross-reactivity.&nbsp;<\/p>\n\n\n\n<p>\u201cYou can have a cross-reaction with certain foods that share certain antigens, certain components, with the cannabis plant itself,\u201d Silvers said.&nbsp;&nbsp;<\/p>\n\n\n\n<p>Such foods may include tomatoes and fruits containing pits, such as peaches, he said. It's a<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3584742\"><strong> <\/strong>similar cross-reactivity<\/a> to what is seen in people with ragweed allergies who might experience symptoms such as itchy mouth if they eat fruit in the melon family, he added.&nbsp;<\/p>\n\n\n\n<p>\u201cThe same thing goes with cannabis and tomatoes and peaches and almonds and a number of other foods \u2026 eggplant, grapefruit, apples,\u201d Silvers said.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/h9mrF9vaiCOcxjorKj-mddBUjjkfhgcJoFLXql6DdzYks1dZ-WML6DFd0phhw-_ZdyQoMC6nbWEjUU_UDr9N4NJ9wi9hwHHnPtlk90hyIsKQKWlg5d-aWpNtzzgLbLACyoxFmhfL\" alt=\"CBD oil dropper\"\/><figcaption>There is no clinical evidence CBD can help allergies. Photo by: Gina Coleman\/Weedmaps<\/figcaption><\/figure>\n\n\n\n<p>He also noted that the type of allergic reaction depends on the type of exposure. In addition to cannabis pollen allergies and food-based allergies, skin allergies are also a possibility. \u201cTouching the plant can very easily lead to dermatitis, itching, and skin reactions,\u201d he said.&nbsp;&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-can-cbd-help-with-allergies\"><strong>Can CBD help with allergies?<\/strong><\/h2>\n\n\n\n<p>While there isn't much research supporting the idea that CBD can help the discomfort associated with common allergy symptoms, there is some research related to its general effects on inflammation, which is part of the body's allergic reaction process. A study published in the Journal of Pharmacology and Experimental Therapeutics in 2018 showed that CBD was effective in reducing inflammation associated with allergic contact dermatitis in a lab model using human cells.&nbsp;<\/p>\n\n\n\n<p>According to Silvers, there is no clinical evidence that CBD products can treat allergies. While there is experimental laboratory research suggesting anti-inflammatory effects exist, there's no clinical patient substantiation.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><em>Major contributions from <a href=\"https:\/\/weedmaps.com\/learn\/subject-matter-expert\/apoe\" target=\"_blank\" rel=\"noreferrer noopener\">Dr. Adie Rae<\/a>.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Whether it's sniffling, watery eyes, itching, or asthma, many of us are all too familiar with symptoms of allergies.&nbsp; According to the Asthma and Allergy Foundation of America, allergies are the sixth leading cause of chronic illness in the US. There were 19.2 million adults...<\/p>\n","protected":false},"author":15,"featured_media":105,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[11],"tags":[1114,1683,1728,1802,1803],"class_list":["post-104","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cbd","tag-cbd-side-effects","tag-cannabidiol-studies","tag-cbd-medical-research","tag-cbd-allergy","tag-cannabinoid-safety-research"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Can You Have an Allergic Reaction to CBD Oil?<\/title>\n<meta name=\"description\" content=\"Learn about the potential for hemp allergy and allergic reactions to CBD oil. 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