This strain is potent. Most users report feeling very happy and uplifted after the first few hits. This is followed by a numbing sensation that envelopes the body, which culminates into a feeling of nearly overwhelming laziness. The desire to sleep after using Black Domina can be too powerful to ignore. The negative effects are typical: dry eyes and mouth, occasional dizziness, anxiety and paranoia. The strong Indica effects of this strain make it ideal for night use, which makes it useful to insomniacs. Patients often report that it alleviates migraines, nausea, and severe aches and pains. Many people choose it for the relief of stress, anxiety, and depression. Black Domina is highly regarded by doctors and dispensaries as a good medical strain.